We meet weekly on Fridays at 1 pm, to discuss articles within the broad area of evolutionary genetics, including but not limited to population genomics. Occasionally we also have our journal club at the Gamla Orangeriet, in the Botanical Garden. Below you can find the papers we will be reading and discussing.
September 14th: Early history and transition to selfing in Arabidopsis thaliana
Jörg will lead the discussion of this recent paper by Durvasula and colleagues: Durvasula et al. 2017. African genomes illuminate the early history and transition to selfing in Arabidopsis thaliana. PNAS 114: 5214-5218
April 28th: Supergene evolution
We will discuss a recent paper on the genetic architecture of the Primula S-locus supergene: Li et al. 2016. Nature Plants.
Location: N340, DEEP N340, Stockholm University
April 7th: Selection on reproductive genes in plants
We will discuss an MBE paper from 2013 by Arunkumar et al. on the impact of selection on genes expressed in pollen in Capsella grandiflora.
Location: N491, DEEP, Stockholm University
March 10th: Serial founder events and mutational load
We will discuss a recent paper in PNAS by Henn et al. on the impact of serial bottlenecks on genetic load in human populations.
Location: N491, DEEP, Stockholm University.
February 24th: The effect of an extreme and prolonged bottleneck on patterns of deleterious variation
We will discuss a recent paper in Genetics where Pedersen et al. combine analyses of population genomic data with simulations, to characterise the effects of a long and severe bottleneck on deleterious variation and evaluate different measures of genetic load. Location: N491, DEEP, Stockholm University.
February 9th: Transposable elements and gene regulation
We will discuss a recent paper in eLife entitled “Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation” by Stuart et all, on Friday at 2.30 pm at Gamla orangeriet.
January 25th: Origin of the allotetraploid Arabidopsis suecica
We will discuss a recent paper in MBE entitled “Genome sequencing reveals the origin of the allotetraploid Arabidopsis suecica” by Novikova et al., on Thursday at 1 pm at SciLifeLab (Hertz, Gamma 6).
August 19th: Recent literature JC
Everyone picks 2-3 recent papers of interest and summarizes them. This time we will meet at 1 pm at Gamla Orangeriet.
June 10th: Ancient DNA from sediments
Engy will present this review paper on ancient DNA from sediments and their impact on reconstruction of past biodiversity.
Birks et al. 2016. How have studies of ancient DNA from sediments contributed to the reconstruction of Quaternary floras? New Phytologist 209: 499-506
June 2nd: Regions of open chromatin are enriched for variants with effects on gene expression and phenotypic trait variation in maize
Rodgers-Melnick E, Vera DL, Bass HW and Buckler ES 2016. Open chromatin reveals the functional maize genome. Proceedings of the National Academy of Sciences:201525244
Presenter: Robert. Note: On Thursday, at SU.
May 27th: Detecting balancing selection
Jörg will present this review paper on the limits and prospects for detecting balancing selection in genomes. Note that we will start at 3 pm!
Fijarczyk and Babik. 2015. Detecting balancing selection in genomes: limits and prospects. Molecular Ecology 24: 3529-45.
May 20th: Recent selection for self-compatibility in Leavenworthia
This week we will read a recent paper on population genetic patterns surrounding the S-locus in a self-compabtible population of Leavenworthia alabamica:
Herman AC and Schoen DJ. Recent selection for self-compatibility in a population of Leavenworthia alabamica. Evolution Advance Access doi: 10.1111/evo.12937
May 13th: Genomic distribution of conserved noncoding elements and association with gene expression in mammals
Babarinde & Saitou 2016 MBE Genomic locations of conserved noncoding sequences and their proximal protein-coding genes in mammalian expression dynamics
April 29th: Linked selection and demographic inference
Schrider D, Shanku AG, Kern AD. 2016. Effects of linked selective sweeps on demographic inference and model selection. bioRxiv Presenter: Tanja
Cornille A, Salcedo A, Kryvokhyzha D, Glémin S, Holm K, Wright S, Lascoux M. 2016. Genomic signature of successful colonization of Eurasia by the allopolyploid shepherd’s purse (Capsella bursa‐pastoris). Molecular Ecology 25:616-629. Presenter: Ben
Note: We will meet at the Gamla Orangeriet this week.
April 8th: First recent literature JC
Everyone picks 3-5 recent papers of interest and summarizes them. Here is the list of papers and links that we discussed.
Note: We will meet at the Gamla Orangeriet this week.
April 1st: Linked selection and Lewontin’s paradox
Ben will present this commentary: Coop G. 2016. Does linked selection explain the narrow range of genetic diversity across species? BioRxiv doi: http://dx.doi.org/10.1101/042598
March 18th: Sex speeds adaptation by altering the dynamics of molecular evolution
McDonald MJ, Rice PJ, Desai MM. 2016. Sex speeds adaptation by altering the dynamics of molecular evolution. Nature doi:10.1038/nature17143
March 11th: Evolution of DNA methylation
Ben and Kim will present this short review paper on DNA methylation: Zhong. 2016. Comparative epigenomics: a powerful tool to understand the evolution of DNA methylation. New Phytologist 210:76-80
February 17th: The complications of inferring relaxed purifying selection in non equilibrium situations. NB change of time: Friday at 10.30 am!
Tanja will present this short review paper: Brandvain and Wright. 2016. The limits of natural selection in a nonequilibrium world. Trends in Genetics, in press.
February 12th: Cis-regulatory evolution
Kim will present this paper on cis-regulatory evolution: Fyon et al. 2015. Enhancer runaway and the evolution of diploid gene expression. PLoS Genetics 11(11): e1005665
November 20th: Evolution and silencing of repeats in Arabidopsis and relatives
We will read and discuss this paper on the age distribution and silencing of repeats in the Arabidopsis thaliana genome: Maumus F, Quesneville H. 2014. Ancestral repeats have shaped epigenome and genome composition for millions of years in Arabidopsis thaliana. Nat Commun 5:4104.
This paper is also relevant for those going to Brandon Gaut’s seminar at EBC in Uppsala on Tuesday November 17th at 14.00 (Lindahlsalen).
November 12th (NOTE, Thursday, at SciLifeLab!): Organizing computational biology projects
We will read and discuss organization of genomics projects, based on this paper in PLoS Computational Biology: Stafford Noble 2009. A quick guide to organising computational biology projects. PLoS Computational Biology 5(7): e1000424.
November 6th: Evolution of dominance at the Brassicaceae self-incompatibility locus
Durand et al. 2014. Dominance hierarchy arising from the evolution of a complex small RNA regulatory network. Science 346:1200–1205.
October 30th: Dissecting the genetic basis of a complex cis-regulatory adaptation
October 23rd: Widespread genomic signatures of natural selection in hominid evolution
McVicker et al. 2009. PLoS Genetics 5: e1000471 Presenter: Ben
October 8th: Detecting recent selective sweeps in the presence of background selection and varying mutation rate
NOTE! On THURSDAY, at SciLifeLab, gamma 6, before lunch.
Huber CD, DeGiorgio M, Hellman I, Nielsen R. Molecular Ecology. 2015. doi: 10.111/mec. 13351 Presenter: Ben
September 26th: Interaction between gene expression and purifying selection in maize
Dilip Pophaly S, Tellier A. 2015. Population level purifying selection and gene expression shape sub genome evolution in maize. Molecular Biology and Evolution, in press. Presenter: Kim
September 17th: Frequent adaptation and the McDonald-Kreitman test
NB! On THURSDAY, at SciLifeLab, gamma 6.
We will discuss this paper on the impact of linked selection on analyses based on extensions of the classic McDonald-Kreitman test.
Messer PW, Petrov DA. 2013. Frequent adaptation and the McDonald-Kreitman test. PNAS 110:8615-8620 Presenter: Tanja
September 11th: Allopolyploidy and gene expression evolution
We will discuss this paper which deals with genetic and epigenetic mechanisms for gene expression changes in polyploids:
Shi et al. 2015. Genome-Wide Dosage-Dependent and -Independent Regulation Contributes to Gene Expression and Evolutionary Novelty in Plant Polyploids. Molecular Biology and Evolution 32: 2351-2366. Presenter: Kim
September 4th: Mating systems and molecular evolution
For this session, we will discuss a recent paper on patterns of molecular evolution and efficacy of natural selection in outcrossing and selfing snails: Burgarella et al. 2015. Molecular Evolution of Freshwater Snails with Contrasting Mating Systems. Molecular Biology and Evolution, 32:2403–2416 Presenter: Ben
August 28th, 2015: Heterozygosity and mutation rates – a feed-forward loop?
We will discuss Yang et al. 2015. Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature 523: 463-467. Presenter: Tanja